Analytical NanoSystems (NSysA)

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Group presentation

Our group is located at the National Engineering School of Chemistry, Biology and Physics (ENSCBP). The main activities are focused on the development of new analytical tools and techniques with a special accent on miniaturized systems applied to the study of biological systems and biomedical issues. Our research addresses problems resulting from the ever increasing demands of our modern society concerning various aspects like public health, security and environmental issues. In order to tackle these problems, the discipline of Analytical Chemistry has to evolve constantly and improve its performance.

Distinguishing molecules with almost identical physico-chemical properties, tracking their evolution with a high spatio-temporal resolution, detecting them at the cell or subcellular level in complex environments, are some of the challenges that we work on. With this respect current projects include biofunctionalized nanoparticles, chemical sensors for biology, electrochemistry of biosystems, micro/nanoscale imaging and smart functional nanostructures. In order to work successfully on these topics we have combined in our group an interdisciplinary team with know-how ranging from electrochemistry and optics to organic or colloidal synthesis and cell biology. The resulting synergy is the guaranty for original systems dedicated to contribute to the solution of some of the current problems in the field of Analytical Chemistry.

Research activity

> Chemical sensors for biology (molecular probes for detection of bio-relevant species, electrochemical biosensors).
> Micro/nanoscale imaging (optical tools for imaging & enhanced coupled methodologies, electrochemical imaging).
> Smart functional nanostructures (micro/nanogels for drug delivery, nanostructured electrodes, functional inorganic particles).
> Electrochemistry of biosytems (cell & sub-cellular analysis, protein/peptide electrochemistry, electron transfer in DNA).

Key Words

Electrochemistry, biochemistry, inorganic and organic synthesis, soft matter, colloids, optics, spectroscopy, micro/nanomaterials, chemical sensors, biosensors, supramolecular chemistry, fluorescence, electrochemiluminescence, neurotransmitters, electrochemical imaging, microgels, drug delivery, stimuli-responsive polymers, glucose, porous electrodes, Janus particles, bipolar electrochemistry, single cell electrochemistry, reactive oxygen and nitrogen species, mitochondria, DNA, peptides.

Group members

Dr. Stéphane Arbault (CNRS Research Director & Group Leader)
Dr. Laurent Bouffier (CNRS Researcher)
Mr. Patrick Garrigue (IPB Engineer)
Dr. Bertrand Goudeau (CNRS Assistant Engineer)
Pr. Alexander Kuhn (IPB Professor)
Mrs. Véronique Lapeyre (UB1 Assistant Engineer)
Dr. Adeline Perro-Marre (IPB Assistant Professor)
Dr. Valérie Ravaine (IPB Professor)
Mrs. Aline Simon-Lalande (IPB Technician)
Pr. Neso Sojic (IPB Professor)
Dr. Dodzi Zigah (UB1 Assistant Professor)

Brivatech: Technology Transfer

Dr. Stéphane Reculusa (ADERA Engineer)

Recent publications

Early diagnosis of fungal infections using piezomicrogravimetric and electric chemosensors based on polymers molecularly imprinted with d-arabitol
M. Dabrowski, P. Sindhu Sharma, Z. Iskierko, K. Noworyta, M. Cieplak, W. Lisowski, S. Oborska, A. Kuhn, W. Kutner
Biosens. Bioelectron. 2016, in press, DOI: 10.1016/j.bios.2015.12.088.

Redox- and pH-responsive nanogels based on thiolated poly(aspartic acid)
E. Krisch, L. Messager, B. Gyarmati, V. Ravaine, A. Szilágyi
Macromol. Mater. Eng. 2016, in press, DOI: 10.1002/mame.201500119.

One-step preparation of bifunctionalized surfaces by bipolar electrografting
L. Koefoed, K. Shimizu, S. U. Pedersen, K. Daasbjerg, A. Kuhn, D. Zigah
RSC Adv. 2016, 6, 3882-3887.

Selective functionalization of graphene peripheries by using bipolar electrochemistry
L. Zuccaro, A. Kuhn, M. Konuma, H. K. Yu, K. Kern, K. Balasubramanian
ChemElectroChem 2016, in press, DOI: 10.1002/celc.201500461.

Original dual microelectrode: writing and reading a local click reaction with scanning electrochemical microscopy
V. Badets, D. Duclos, D. Quinton, O. Fontaine, D. Zigah
Electrochim. Acta 2016, in press, doi:10.1016/j.electacta.2015.10.066.

Dual-color electrogenerated chemiluminescence from dispersions of conductive microbeads addressed by bipolar electrochemistry
A. de Poulpiquet, B. Diez-Buitrago, M. Milutinovic, B. Goudeau, L. Bouffier, S. Arbault, A. Kuhn, N. Sojic
ChemElectroChem 2016, in press, DOI: 10.1002/celc.201500402

Solid-state bipolar electrochemistry: polymer-based light-emitting electrochemical cells
S. Chen, G. Wantz, L. Bouffier and J. Gao
ChemElectroChem 2016, in press, DOI: 10.1002/celc.201500373.

Bipolar electrografting on the inner wall of carbon nanotubes
C. Kumsapaya, J. Limtrakul, A. Kuhn, D. Zigah, C. Warakulwit
ChemElectroChem 2016, in press, DOI: 10.1002/celc.201500379.

Address & contact number

Address : ENSCBP, Building A, 1st floor
Email :
Phone : + 33 5 40 00 22 39
Site Web :


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