Mathieu Pucheault

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Dr. Mathieu Pucheault
CNRS Research Director

Institut des Sciences Moléculaires, Groupe ORGA, UMR 5255
Bâtiment A11, Université de Bordeaux
33405 Talence cedex

Phone +33 (0)5 40 00 67 33
Fax +33 (0)5 40 00 66 32
ORCID : 0000-0002-7001-2803


Directeur de Recherches CNRS
Head of the Sustainable Organic Synthesis Team , ORGA group
Manager of the Synthesis Fluidic Plateform


  • 2016- CNRS Research Director ; UMR 5255 ISM
  • 2011-2016 CNRS Research Scientist ; UMR 5255 ISM
  • 2010 Habilitation à Diriger des Recherches (Univ Rennes 1, France)
  • 2006-2011 CNRS Research Scientist ; UMR 6510 CPM Rennes
  • 2005-2006 Postdoctoral HFSPO Fellowship (Yale University, New Haven , USA)
  • 2004 Chemistry PhD ; (ENSCP, Paris, France)
  • 1998-2002 Ecole Normale Supérieure (Paris, France)
  • 2001 Agrégation de Sciences Physique (Paris, France)
  • 2000 Master Ecole Polytechnique (Palaiseau, France)

Research topics

  • Boron chemistry, aminoboranes, amine borane complexes, boronic acids derivatives, borinic acids
  • Nanocatalysis, nanoparticle formation and characterization, optimization of reaction conditions, recycling, lamellar inorganic materials, clays
  • Flow chemistry, alternative conditions screening, non classical synthesis, supercritical fluids, gas-liquid-solid flow systems, micromixers


64. Biomimetic Cannabinoids Synthesis Revisited. Batch and Flow All-catalytic Synthesis of (±)-ortho-Tetrahydrocannabinols and Analogs from Natural Feedstocks. P. Giorgi, V. Liautard, M. Pucheault, S. Antoniotti Eur J. Org. Chem, 2018, in press

63. Nouveau procédé de stockage de l’hydrogène Mathieu Pucheault FR Demand 1758543, 2017

62. Instant One-Pot Preparation of Functional Layered Double Hydroxides (LDH) via a Continuous Hydrothermal Approach O. Pascu, S. Marre, B. Cacciuttolo, G. Ali, L. Hecquet, M. Pucheault, V. Prevot, C. Aymonier ChemNanoMat, 2017, 49 in press link

61. Nouveau procédé d’oxydation des alcools primaires et secondaires Mathieu Pucheault, Virginie Liautard FR Demand 1755390, 2017

60. Radical Metal-Free Borylation of Aryl Iodides Sandra Pinet*, Virginie Liautard, Mégane Debiais, Mathieu Pucheault* Synthesis , 2017, 49 4759-4768 link special topic “Modern Strategies for Borylation in Synthesis”

59. Nouvelle composition d’isomères du 7,9-dodécadiényl-1-acétate et son procédé de fabrication Mathieu Pucheault,* Virginie Liautard, Loic Guillonneau, Olivier Guerret FR Demand FR1751979, 2017

58. Borinic Acids via Direct Arylation of Amine–Borane Complexes : An Air- and Water-Stable Boron Source Richard, Jimmy ; Birepinte, Mélodie ; Charbonnier, Jean Baptiste ; Liautard, Virginie ; Pinet, Sandra ; Pucheault, Mathieu * Synthesis , 2017, 49 736-744 link Feature Article

57. Pd@[nBu4][Br] as a Simple Catalytic System for N-Alkylation Reactions with Alcohols Bastien Cacciuttolo, Oana Pascu, Cyril Aymonier,* Mathieu Pucheault* Molecules, 2016, 1042-1055 special Issue Cascade Catalysis link

56. Highly efficient Hosomi-Sakurai reaction of aromatic aldehydes catalyzed by Montmorillonite doped with simple bismuth(III) salts. Batch vs continuous flow studies Nelli Elizarov, Mathieu Pucheault and Sylvain Antoniotti* , Chemistry Select, 2016, in press link

55. Simple salts of abondant metals (Fe, Bi, and Ti) supported on Montmorillonite as efficient and recyclable catalysts for regioselective intramolecular and intermolecular hydroalkoxylation reactions of double bonds and tandem processes Irene Notar Francesco, Bastien Cacciuttolo, Oana Pascu, Cyril Aymonier, Mathieu Pucheault and Sylvain Antoniotti* , RSC Adv., 2016, 6, 19807–19818 link

54. Synthesis of borinic acids and borinate adducts using diisopropylaminoborane L. Marciasini, B. Cacciuttolo, M. Vaultier, M. Pucheault* , Org Lett., 2015, 3532-3535 link

53. Procédé de préparation, d’un acide boronique, d’un acide borinique ou de leur dérivés M. Pucheault, M. Vaultier, B. Cacciuttolo, L. Marciasini, 16/06/2015, FR15/555515

52. Advanced Nanostructured Catalysts for Hydroboration VLiautard, O Pascu, C Aymonier,* Mathieu Pucheault*M. Pucheault* , Catalysis Today, 2015, 255, 60-65 Special Issue “Green Catalysis” link

51. Simple metal salts supported on montmorillonite as recyclable catalysts for intramolecular hydroalkoxylation of double bonds in conventional and VOC-exempt solvents I. Notar Francesco, B. Cacciuttolo, M. Pucheault and S. Antoniotti* , Green Chem., 2015, 17, 837-841. link

50. Amine–Borane Complexes : Air- and Moisture-Stable Partners for Palladium-Catalyzed Borylation of Aryl Bromides and Chlorides H. D. S. Guerrand, M. Vaultier, S. Pinet and M. Pucheault*, Adv. Synth. Catal., 2015, 6, 1167-1174. link.

49. ScCO2 assisted preparation of supported metal NPs. Application to catalyst design O. Pascu, B. Cacciuttolo, S. Marre, M. Pucheault, and C. Aymonier*, J. Supercritical Fluids, 2015 105, 84-91 link.

48. Catalysed stereodivergent hydrosilylation with Onium Salts stabilised M(0) Nanocatalysts prepared in scCO2 O. Pascu, V. Liautard, M. Vaultier, M. Pucheault*, and C. Aymonier*, RSC Advances, 2014, 4 (104), 59953 - 59960 link.

47. Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate : from microwave batch chemistry to a scalable continuous-flow process Amandine Xolin, Arnaud Stévenin, Mathieu Pucheault, Stéphanie Norsikian, François-Didier Boyer* Jean-Marie Beau* Org. Chem. Front., 2014, 6156-6161 link.

46. PROCEDE DE PREPARATION D’ACIDES BORINIQUES Mathieu Pucheault, Michel Vaultier, Ludovic D. Marciasini, Bastien Cacciuttolo, French Patent Demand, n° FR 16/54424 16/05/2014.

45. PROCEDE DE PREPARATION DE COMPOSE AROMATIQUE MANDELIQUE ET DE COMPOSE ALDEHYDE AROMATIQUE L. Garel, K. Olivon, O. Back, F. Sarrazin, M. Pucheault French Patent Demand, n° FR , FR 13 61169 15/11/2013.

44. Sequential dehydrogenation-arylation of diisopropylamine-borane complex catalyzed by Palladium nanoparticules
Hélène D.S. Guerrand, Ludovic D. Marciasini, Thomas Gendrineau, Oana Pascu, Samuel Marre, Sandra Pinet, Michel Vaultier, Cyril Aymonier, and Mathieu Pucheault* Tetrahedron, 2014, 6156-6161 link.

43. Borylation of Unactivated Aryl Chlorides under Mild Conditions by Using Diisopropylaminoborane as a Borylating Reagent
Hélène D.S. Guerrand, Ludovic D. Marciasini, Mélissa Jousseaume, Michel Vaultier, Mathieu Pucheault,* Chem. Eur. J., 2014, 5573–5579 link

42. Comparison of homogeneous and heterogeneous Ga(III)-catalysis in the cycloisomerisation of 1,6-enynes
Khadija Ben Hadj Hassen, Kevin Gaubert, Michel Vaultier, Mathieu Pucheault and Sylvain Antoniotti* Green Chemistry Letters and Reviews, 2014, 243-249. link.

41. Book Chapter : Ionic Liquids
Hélène D.S. Guerrand, Michel Vaultier, Mathieu Pucheault Green Process Engineering : From concepts to the industrial applications, 2014, . link.

40. A new route towards fluorescent organic nanoparticles with red-shifted emission and increased colloidal stability
Kassem Amro, Jonathan Daniel, Guillaume Clermont, Talia Bsaibess, Mathieu Pucheault, Emilie Genin, Michel Vaultier,* Mireille Blanchard-Desce* Tetrahedron, 2014, 70 (10), 1903-1909. link.

39. Borylation using group IV metallocene under mild conditions
Ludovic D. Marciasini, Michel Vaultier, Mathieu Pucheault,* Tetrahedron Lett., 2014, 1702–1705 link.

38. A Green Approach for Producing Solvent-free Anisyl Acetate by Enzyme-catalyzed Direct Esterification in Sponge-like Ionic Liquids Under Conventional and Microwave Heating
Pedro Lozano,*, Juana M. Bernal, Almudena Lajarin, Daniel Romera, Eduardo Garcia-Verdugo, Gregorio Sanchez-Gomez, Mathieu Pucheault, Michel Vaultier, M. Isabel Burguete and Santiago V. Luis Curr. Green Chem., 2014, 145-154 link.

37. METHOD FOR PREPARING AMINOARYLBORANE COMPOUNDS OR DERIVATIVES THEREOF Ludovic D. Marciasini, Hélène Guerrand, Michel Vaultier, Mathieu Pucheault, European Patent Demand, n° EP 13306667.0 04/12/2013

36. Iron catalysis and water, a synergy for refunctionalisation of boron
John L. Wood, Ludovic D. Marciasini, Michel Vaultier, Mathieu Pucheault,* Synlett, 2014, 25, 551-555. link

35. Continuous coflow synthesis of hybrid Palladium nanocrystals as catalysts for borylation reaction
Oana Pascu, Ludovic D. Marciasini, Samuel Marre, Michel Vaultier, Mathieu Pucheault,* Cyril Aymonier,* NanoScale, 2013, 5, 12425-12431. link

34. Iron-Catalysed Borylation of Arenediazonium Salts to Give Access to Arylboron Derivatives via aryl(amino)boranes at Room Temperature
Ludovic D. Marciasini, Nicolas Richy, Michel Vaultier, and Mathieu Pucheault,* Adv. Synth. Catal., 2013, 355, 1083–1088 link

L. Vaysse-Ludot, A. Le Flohic, M. Vaultier, M. Pucheault, T. Kaminski US Patent, FR3005658, US8859763, WO2014184501 17/05/2013 link

32. Supercritical Synthesis of Biodiesel
Juana M. Bernal, Pedro Lozano,* , Eduardo García-Verdugo, M. Isabel Burguete, Gregorio Sánchez-Gómez, Gregorio López-López, Mathieu Pucheault, Michel Vaultier and Santiago V. Luis Molecules, 2012, 17, 8696-8719 link

Mathieu Pucheault, Ludovic Marciasini , Michel VaultierEuropean Patent Demand, n° 12 305 854.7 WO2014009169 13/07/2012 link

30. Microfluidic Synthesis of Palladium Nanocrystals Assisted by Supercritical CO2 : Tailored Surface Properties for Applications in Boron Chemistry
Thomas Gendrineau, Samuel Marre, Michel Vaultier, Mathieu Pucheault,*, Cyril Aymonier,* Angew. Chem. Int. Ed., 2012, 51, 8653–8656 link

29. Aminoborylation/Suzuki–Miyaura tandem cross coupling of aryl iodides as efficient and selective synthesis of unsymmetrical biaryls
Ludovic Marciasini , Nicolas Richy , Michel Vaultier and Mathieu Pucheault* Chem. Commun., 2012, 48, 1553-1555 link

28. 28. Book Chapter : Product subclass 28 : Vinyl boranes
Mathieu Pucheault* and Michel Vaultier*, Science of Synthesis 2012, 297-341 link

27. Achieving chemo-, regio- and stereoselectivity in palladium-catalyzed reaction of gamma-borylated allylic acetates
Krishna Kishore Kukkadapu, Aziz Ouach, Pedro Lozano, Michel Vaultier, Mathieu Pucheault* Organic Letters 2011, 13, 15, 4132-4135. link

26. Stabilizing immobilized cellulase by ionic liquids for saccharification of cellulose solutions in 1-butyl-3-methylimidazolium chloride
Pedro Lozano,* Berenice Bernal, Juana M. Bernal, Mathieu Pucheault and Michel Vaultier, Green Chemistry 2011, 13, 1406-1410. link

25. (Bio)catalytic continuous flow processes in scCO2 and/or ILs : Towards Sustainable (Bio)catalytic Synthetic Platforms.
Pedro Lozano,* Eduardo Garcia-Verdugo, Santiago V. Luis, Mathieu Pucheault, Michel Vaultier Current Organic Synthesis 2011, 14, 810-823. link

24. Onium Salt Supported Peptide Synthesis
Céline Roche, Mathieu Pucheault, Michel Vaultier,* Alain Commercon Tetrahedron 2010, 8325-8334. link

23. Exceptional Efficiency of Palladium Nanoparticles Catalyzed Heck Cross-coupling in Binary Task Specific Ionic Liquids
Fatima Hassine, Mathieu Pucheault, Michel Vaultier* Comptes Rendus Chimie 2011, 14, 7-8, 671-679. link

22. Mild, base-free copper-catalyzed N-arylations of heterocycles using potassium aryltrifluoroborates in water under air
Nicolas Joubert, Emmanuel Baslé, Michel Vaultier, Mathieu Pucheault Tetrahedron Letters, 2010, 2994-2997. link

21. Review : Protein Chemical Modification on Endogenous Amino Acids
Emmanuel Baslé, Nicolas Joubert, Mathieu Pucheault Chemistry and Biology, 2010, 213-227. link

20. MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall
Constantin N. Takacs, Sebastian Poggio, Godefroid Charbon, Mathieu Pucheault, Waldemar Vollmer, Christine Jacobs-Wagner, Journal of Bacteriology 2010, 192, 1671-1684. link

19. Towards an efficient microsystem for the real-time detection and quantification of mercury in water based on a specifically designed fluorogenic binary task specific ionic liquid
Faïdjiba Loe-Mie, Gilles Marchand, Jean Berthier, Nicolas Sarrut, Mathieu Pucheault, Mireille Blanchard-Desce, Françoise Vinet and Michel Vaultier Angewandte Chemie International Edition, 2010, 424-427. link

18. Chapitre de Livre : Liquides Ioniques
Mathieu Pucheault, Michel Vaultier, Green Process Engeneering Dunod 2010. Prix Roberval 2011 link

17. Review : Task Specific Ionic Liquids and Task Specific Onium Salts
Mathieu Pucheault, Michel Vaultier, Topics in Current Chemistry 2009, 290, 83-126 link
Reviewed in Chemistry World 2010, 60

16. Organic-Inorganic Hybrid Materials for Enantioselective Organocatalysis
Vivek Srivastava, Kevin Gaubert, Mathieu Pucheault, Michel Vaultier ChemCatChem, 2009, 1, 94-98. link

15. Sels d’onium et leur utilisation pour la detection et le dosage des metaux
Gilles Marchand, Faidjiba Loe-Mie, Mathieu Pucheault, Mireille Blanchard-Desce, Michel Vaultier EP2112138, 21/04/2008. link

14. Targeted Intracellular Protein Degradation Induced by a Small Molecule : En Route to Chemical Proteomics
Ashley R. Schneekloth, Mathieu Pucheault, Hyun Seop Tae, Craig M. Crews, Bioorganic & Medicinal Chemistry Letters 2008, 18, 5904-5909. link

13. Review : Natural products : chemical instruments to apprehend biological symphony
Mathieu Pucheault* Organic and Biomolecular Chemistry 2008, 424-432. link
Most accessed paper during 1st semester 2008
Top 10 most accessed paper in 2008

12. Cover : Onium Salt Supported Organic Synthesis in water : application to Grieco’s multicomponent reaction
Aziz Ouach, Said Gmouh, Mathieu Pucheault and Michel Vaultier, Tetrahedron 2008, 64, 1962-1970 . link

11. Onium Salt Supported Organic Synthesis in Water : Application to Ugi’s 4-Components Reaction
Aziz Ouach, Mathieu Pucheault and Michel Vaultier, Heterocycles 2007, 73, 461-467. link

10. Task Specific Onium Salts and Ionic liquids as Soluble Supports in Grieco’s Multicomponent Synthesis of tetrahydroquinolines
Fatima Hassine, Said Gmouh, Mathieu Pucheault and Michel Vaultier, Monaschefte für Chemie 2007, 1167-1174. link

9. Task Specific Onium Salts (TSOSs) as efficient soluble supports for Zard radical addition to olefins
Julien Verron, Jean-Michel Joerger, Mathieu Pucheault and Michel Vaultier, Tetrahedron Letters 2007, 4055-4057 . link

8. Construction of highly substituted stereodefined dienes via cross-coupling of alpha-allenic acetate
John S. Schneekloth, Jr., Mathieu Pucheault, Craig M. Crews, European Journal of Organic Chemistry 2007, 40-43. link

7. Carbinol derivatives via rhodium-catalyzed addition of potassium trifluoro(organo)borates
Mathieu Pucheault, Sylvain Darses, Jean-Pierre Genet, Chemical Communication 2005, 4714-4716. link

6. Potassium trifluoro(organo)borates in rhodium-catalyzed 1,4-additions to alpha,beta-unsaturated esters
Laure Navarre, Mathieu Pucheault, Sylvain Darses, Jean-Pierre Genêt, Tetrahedron Letters 2005, 127, 4247-4250. link

5. Direct access to ketones from aldehydes via rhodium-catalyzed cross-coupling reaction with potassium trifluoro(organo)borates 
Mathieu Pucheault, Sylvain Darses, Jean-Pierre Genêt, J. Am. Chem. Soc, 2004, 126, 15356-15357. link

4. General access to b-arylamides via asymmetric 1,4-additions of potassium trifluoro(organo)borates
Mathieu Pucheault, Valérie Michaut, Sylvain Darses, Jean-Pierre Genêt, Tetrahedron Lett. 2004, 45, 4729-4732. link

3. "Potassium organotrifluoroborates : new partners in catalytic enantioselective conjugate additions to enones"
Mathieu Pucheault, Sylvain Darses, Jean-Pierre Genêt, Tetrahedron Lett. 2002, 43, 6155-6157. link

2. "Potassium organotrifluoroborates in rhodium-catalyzed asymmetric 1,4-additions to enones"
Mathieu Pucheault, Sylvain Darses, Jean-Pierre Genêt Eur. J. Org. Chem. 2002, 3552-3557. link

1. Efficient access to perfluoroalkylated aryl compounds by Heck reaction
Sylvain Darses, Mathieu Pucheault, Jean-Pierre Genêt Eur. J. Org. Chem. 2001, 1121-1128 link

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